tert-Butyl 5-bromo-1H-indazole-1-carboxylate
- Catalog NO.:A8856
- CAS No. : 651780-02-8
- Molecular Formula:C12H13BrN2O2
- Molecular Weight: 297.15
Note*
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Bulk Inquiry
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Product Details
CAS Number | 651780-02-8 | Appearance | Light yellow viscous liquid |
Catalog Number | A8856 | MDL Number | MFCD08435913 |
Molecular Formula | C12H13BrN2O2 | Molecular Weight | 297.15 |
Boiling Point | 377°C at 760 mmHg | Melting Point | |
Flash Point | Density | ||
Synonyms | tert-Butyl 5-bromo-1H-indazole-1-carboxylate | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
ABT-737 is an orally available inhibitor of the nuclear enzymes poly(ADP-ribose) polymerase (PARP) 1 and 2, with potential antineoplastic activity. Upon administration, ABT-767 selectively binds to PARP 1 and 2, thereby preventing repair of damaged DNA via the base excision repair (BER) pathway. This agent enhances the accumulation of DNA strand breaks and promotes genomic instability eventually leading to apoptosis. ABT-767 may enhance the cytotoxicity of DNA-damaging agents and reverse tumor cell chemo- and radioresistance. |